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Neurology & Pain Management Coding:

Remember Chemodenervation Components for Complete Coding

Lead-up to procedure could include EMG, NCS — and more.

When a patient suffers from conditions such as facial tics, cervical dystonia, or spasticity, the neurologist might rely on chemodenervation to remedy the condition.

Chemodenervation is a therapeutic procedure involving the injection of neurotoxins — most commonly onabotulinumtoxinA (Botox®) — to temporarily inhibit nerve signals to muscles. This results in reducing involuntary spasms, dystonia, and spasticity.

Read on to learn more about properly coding chemodenervation services.

Understand Key Assessment Criteria

Providers determine medical necessity for chemodenervation based on the presence of chronic involuntary muscle hyperactivity (for example, spasticity, dystonia, or chronic migraines) that has not responded to conservative therapies. Diagnosis involves physical exams to identify specific muscles, review medical history, and confirm prior treatment failure.

Condition diagnosis: Patients who need chemodenervation often present with spasmodic torticollis, cervical dystonia, blepharospasm, chronic migraines, or muscle spasticity from stroke, multiple sclerosis, or cerebral palsy. For chronic conditions like migraines, clinicians must document that the patient has tried and failed multiple preventive therapies.

During the physical exam, the physician must locate and clearly document the specific muscles causing spasm or rigidity. The goal is to reduce pain, improve function, and increase range of motion by temporarily blocking neuromuscular activity.

Assessment tools: A provider will conduct an office/outpatient evaluation and management (E/M) service (99202-99215 [Office or other outpatient visit for the evaluation and management of a new/established patient… ]) to assess muscle tone, movement patterns, and pain levels. They’ll make decisions about chemodenervation within the first or second visit. The provider might also use a diagnostic procedure to assess the patient, depending on patient specifics. You can report an E/M on the same day of a procedure with modifier 25 (Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service), if the service is for a new condition or exceeds the typical pre-procedure assessment.

Identify Imaging and Chemodenervation Codes for Treatment

The provider will often use electromyography (EMG), nerve conduction study (NCS), or ultrasound (US) to identify the precise muscle causing the issue before a chemodenervation injection, and you can code it separately in addition to the key treatment. Code EMG and NCS based on the number of extremities tested and whether they are performed together. Common codes include 95907 (Nerve conduction studies; 1-2 studies) through 95913 (… 13 or more studies) for NCS.

If the provider performs EMG along with the NCS, include +95885 (Needle electromyography, each extremity, with related paraspinal areas, when performed, done with nerve conduction, amplitude and latency/velocity study; limited (List separately in addition to code for primary procedure)) or +95886 (… complete, five or more muscles studied, innervated by three or more nerves or four or more spinal levels (List separately in addition to code for primary procedure)); if the provider performs EMG without NCS, choose from 95860 (Needle electromyography; 1 extremity with or without related paraspinal areas) through 95864 (… 4 extremities with or without related paraspinal areas).

doctor with syringe

Check for US: The provider might use US guidance during these procedures. If this occurs you can report it separately, typically with 76942 (Ultrasonic guidance for needle placement (eg, biopsy, aspiration, injection, localization device), imaging supervision and interpretation).

Choose Chemodenervation Code Carefully

Clinical effects of chemodenervation injections typically provide relief for eight to 16 weeks. Choose from the following codes for chemodenervation procedures:

  • 64611 (Chemodenervation of parotid and submandibular salivary glands, bilateral) through 64617 (Chemodenervation of muscle(s); larynx, unilateral, percutaneous (eg, for spasmodic dysphonia), includes guidance by needle electromyography, when performed)
  • 64642 (Chemodenervation of one extremity; 1-4 muscle(s)) through 64653 (Chemodenervation of eccrine glands; other area(s) (eg, scalp, face, neck), per day)
  • 67345 (Chemodenervation of extraocular muscle)

Get Documentation Right for Clean Claims

Documentation for chemodenervation claims must clearly establish medical necessity —  detailing the diagnosis, specific muscles treated, dosage per muscle, and anatomical locations. Records must include patient history, failure of conservative therapies, and clinical effectiveness, particularly for ongoing treatments, often requiring a diagram. (According to the American Academy of Ophthalmology, using a diagram showing the injection sites is recommended to prove functional [noncosmetic] treatment.)

The notes accompanying the claim should also include documented consent from the patient for the procedure and details such as muscles injected, drug dosage, and guidance used (if any).

Make note: Some local coverage determinations (LCDs) require objective documentation of functional improvement, noting the effect of previous injections to support continuation.

Check out These Clinical Scenarios

Now that you’ve gotten the basics of chemodenervation, take a look at the codes in action. The first scenario shows a provider deciding that a patient could benefit from chemodenervation; the second scenario shows a clinical chemodenervation scenario.

Scenario 1: A 55-year-old established patient presents with acute episodic dyspnea and suspected laryngeal spasm. The patient reports sudden brief episodes of choking and inability to breathe, high-pitched noise on inhalation, and throat tightness. The provider takes a detailed history, focusing on potential triggers like gastroesophageal reflux disease (GERD) or environmental irritants. They then perform a head and neck examination, documenting normal vocal cord structure but assessing for signs of irritation. A flexible laryngoscopy is performed to observe the larynx for closure or spasm. The provider determines that the patient could receive chemodenervation injections to improve symptoms and quality of life. The patient takes information on the procedure for further review.

For this encounter, you would report:

  • 99214 (Office or other outpatient visit for the evaluation and management of an established patient, which requires a medically appropriate history and/or examination and moderate level of medical decision making. When using total time on the date of the encounter for code selection, 30 minutes must be met or exceeded.) for the E/M
  • Modifier 25 appended to 99214 to show it is distinct from the procedure
  • 31575 (Laryngoscopy, flexible; diagnostic) for the laryngoscopy
  • J38.5 (Laryngeal spasm) appended to 99214 and 31575 to represent the patient’s spasms

Scenario 2: A 46-year-old patient with chronic cervical dystonia (spasmodic torticollis) presents for treatment of severe neck spasms. The physician performs chemodenervation, injecting a total of 150 units of Botox® into both sides of the sternocleidomastoid and splenius capitis muscles. 

For this encounter, you’d report:

  • 64616: (Chemodenervation of muscle(s); neck muscle(s), excluding muscles of the larynx, unilateral (e.g., for cervical dystonia, spasmodic torticollis)) for the chemodenervation
  • Modifier 50 (Bilateral procedure) appended to 64616 to indicate a bilateral procedure
  • J0585 (Injection, onabotulinumtoxinA, 1 unit) x 150 for the Botox injection
  • G24.3 (Spasmodic torticollis) appended to 64616 and J0585 to represent the patient’s condition.

Jessica Sullivan, CPC, COBGC, COSC, Consultant, Pinnacle Enterprise Consulting Services (PERCS)

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