Hey
Can we use Vitamin B12 deficiency code 266.2 for this???
Pernicious anemia (also known as Biermer's anemia, Addison's anemia, or Addison–Biermer anemia) is one of many types of the larger family of megaloblastic anemias.
It is caused by loss of gastric parietal cells which are responsible, in part, for the secretion of intrinsic factor, a protein essential for subsequent absorption of vitamin B12 in the ileum.
Usually seated in an atrophic gastritis, the
autoimmune destruction of gastric parietal cells leads to a lack of intrinsic factor.
Since the absorption from the gut of normal dietary amounts of vitamin B12 is dependent on intrinsic factor, the loss of intrinsic factor leads to vitamin B12 deficiency. While the term 'pernicious anemia' is sometimes also incorrectly used to indicate megaloblastic anemia due to any cause of vitamin B12 deficiency, its proper usage refers to that caused by atrophic gastritis, parietal cell loss, and lack of intrinsic factor only.
The loss of ability to absorb vitamin B12 is the most common cause of adult vitamin B12 deficiency. Such a loss may be due to pernicious anemia (with loss of intrinsic factor) or to a number of other conditions that decrease production of gastric acid, which also plays a part in absorption of vitamin B12 from foods.
Pernicious anemia is often used synonymously with vitamin B12 deficiency. However, pernicious anemia specifically
refers to anemia resulting
from vitamin B12 deficiency caused by an autoimmune metaplastic atrophic gastritis with loss of intrinsic factor
And also as per causes of Vitamin B12 deficiency, Lack of intrinsic factor (due to pernicious anemia, destruction of gastric mucosa, gastric surgery, or gastric bypass surgery)
Intrinsic factor inhibition
Decreased acid secretion
Small-bowel disorders (eg, inflammatory bowel disease, sprue, cancer, biliary or pancreatic disorders)
Competition for vitamin B12 (in fish tapeworm infestation or blind loop syndrome)
AIDS