From a CPT coding perspective, if the same lesion is biopsied, and subsequently removed during the same operative session, then you should only report the code for the removal of the lesion. However, if one lesion is biopsied, and a separate lesion is removed during the same operative session, then it would be appropriate to report a code for the biopsy of one lesion, and an additional code for the removal of the separate lesion.
Under certain circumstances the physician may need to indicate that a procedure or service was distinct or independent from other services performed on the same day. Modifier -59, Distinct Procedural Service, is used to identify procedures/services that are not normally reported together, but are appropriate under the circumstances. This may represent a different session or patient encounter, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same physician. Therefore, if one lesion is biopsied, and a separate lesion is removed, then it would be appropriate to append modifier -59 to the code reported for the biopsy procedure