Question: The patient's post-operative diagnoses were dysfunctional voiding and interstitial cystitis with Hunners' ulcer. In fact my urologist was so sure the patient had interstitial cystitis that he administered dimethyl sulfoxide (DMSO), hydrocortisone, and Heparin before the patient left the operating room and dictated that if she didn't show some remission of symptoms following this one instillation, she would be scheduled for 8 weeks of DMSO in the office. The path report diagnosis came back as acute and chronic cystitis. Given this information, are we correct in reporting 52260? Answer: The problem: Your diagnosis code should be 595.1 (Chronic interstitial cystitis). Since the urologist also performed a separate bladder biopsy you should also report 52204 (Cystourethroscopy, with biopsy[s]). Append modifier 59 (Distinct procedural service) to identify the separate nature of these two bundled procedures. The reason the urologist performed the biopsy was to rule out carcinoma in situ, an early form of bladder cancer, with specifically known pathological findings and producing symptoms similar to interstitial cystitis (hematuria, dysuria, or urinary frequency).