Radiation oncology coders may soon be sorting out codes for ibritumomab tiuxetan therapy (Zevalin) a newly approved radioimmunotherapy treatment for patients with low-grade, follicular or transformed B-cell non-Hodgkin's lymphoma (NHL). The First Days of the Cycle - Imaging Dose Zevalin represents a new kind of cancer-killer - a monoclonal antibody with an extra kick of radiation attached that boosts its tumor-killing power. Monoclonal antibody therapy with Zevalin is administered by intravenous infusion, generally over the course of about a week on an outpatient basis. Between two and 24 hours after the infusion of indium-111 Zevalin, the radiologist takes whole body images with a gamma camera. Additional images may be taken again 48 to 72 hours later. The treatment team uses these images to chart the path of the radio-tagged drug in the body and to assess how well it is targeting tumor cells. For each biodistribution scan performed, Medicare accepts one of the following codes: "Our clinic did the whole body imaging with 78802," Smith says. Medicare is differentiating between hospitals and diagnostic centers, DeLioa says, "so as a free-standing diagnostic center, we are using A4641 (Diagnostic radiopharmaceutical), the drug name, and the NDC number." DeLioa says his facility is still waiting for clarification on drug codes, but for now, hospitals should use the J code for the indium-111 (J3490), while freestanding imaging centers should use A4641. Next Comes the Therapeutic Dose About one week after the initial treatment day, if all has gone well, the patient returns for a second intravenous infusion of rituximab (250 mg/m2) followed by yttrium-90 Zevalin, the therapeutic portion of the regimen. The radiation facility administers yttrium-90 Zevalin through an intravenous infusion lasting about 10 minutes. Smith says she has also contacted all the insurance companies that they work with prior to submitting claims. "I think that is important to reimbursement because we're not just sending a claim blindly. We also worked very closely with our pharmaceutical rep," she says.
To submit clean claims, coders will want to distinguish between pretreatment imaging and therapeutic codes because Zevalin administration is a two-step process that is "part diagnostic and part therapeutic," says Sandy Smith, a coding specialist at Tristan Associates in Harrisburg, Pa.
Zevalin coding can get very tricky because delivery of the regimen requires lots of providers. "Coordination of care is absolutely critical," stresses Paul DeLioa, CEO of Tristan Associates, which is a Zevalin-ready clinic. As part of the coordinated team, radiology coders will have to know which codes they need to get right for each phase of the therapy. Radiology coders will primarily be charged with assigning correct codes for imaging, which occurs during the first phase of the process, and for reporting the Zevalin doses.
Here's how it works. On the first day, the patient receives an intravenous infusion of 250 mg/m2 rituximab (Rituxan, J9310), which targets the cancer cells. Following this infusion, the patient travels to a nuclear or radiation oncology facility to receive an imaging dose of indium-111 Zevalin (A4641).
"We did that twice, once when the patient first came in for the indium-111 and then when they came in for the second dose of yttrium-90," DeLioa says.
The Radiology Coder should report the scanning and the radiopharmaceutical drug, while the oncology department will be billing for the Rituxan, Smith says. Payment for infusion is packaged into the imaging scans and should not be billed separately.
For free-standing diagnostic centers, two codes are associated with this part of the treatment cycle, DeLioa and Smith say. Submit administration of the therapeutic dose with 79400 (Radiopharmaceutical therapy, nonthyroid, nonhematologic) and the radiation handling with 77790 (Supervision, handling, loading of radiation source). Medicare does not reimburse imaging studies after this infusion, according to a CMS Aug. 21, 2002, program memorandum (AB-02-120), but individual clinics may choose to do a second scan when the patient comes in for the yttrium-90 dose.
A code for radiation handling - 77750 (Infusion or instillation of radioelement solution) - appears in a potential coding sheet published by the pharmaceutical manufacturer IDEC, but not in Medicare guidelines, which state explicitly that "no other codes than the ones described & should be reported on claims for Zevalin."
Coding protocols for 78802 issued by Zevalin's manufacturer differ slightly from the CMS instructions in program memo AB-02-120. The main difference lies in the number of whole body scans recommended (up to three by IDEC) and the number reimbursed by Medicare.
CMS says that "only one of the three imaging codes should be used, with the units of service of one (1) that would include all the imaging studies performed, regardless of the number of images or number of days required to perform the imaging."
Though Medicare will only pay for one scan, some private insurance companies may reimburse for two, says Byron Hare, a representative specialist with IDEC's reimbursement hotline.
Some local carriers may also diverge from the literal application of Medicare guidelines. Smith says her office's local carrier (HGC Administrators) is telling her to bill for both scans (2 x 78802) because they're done on two different days. "We've submitted a claim based on that criteria with a -59 modifier (Distinct procedural service)," she says, but how reimbursement will shake out is still unknown. Coders should comb through LMRPs and have frank discussions with their local carriers about how often they may submit for imaging studies.