Question: Illinois Subscriber Answer: In general terms, when the physician performs a bone marrow aspiration and biopsy at the same site during the same session, you should report 38221 (Bone marrow; biopsy, needle or trocar) for the biopsy. For the aspiration, you should add G0364 (Bone marrow aspiration performed with bone marrow biopsy through the same incision on the same date of service) if the private payer accepts that code. Or you instead may be able to report 38220 (Bone marrow; aspiration only) in addition to 38221 if the payer doesn't accept G0364. In contrast, if you're reporting to Medicare (or a payer that shares Medicare's rules), you should report both 38221 and G0364 to indicate performance of the two services through the same incision at the same session. As Medicare's Correct Coding Initiative Manual, Chapter V, Section E, explains it: When the physician performs bone marrow aspiration and biopsy at separate sites or separate patient encounters, you may report 38220 and 38221. "Separate sites include bone marrow aspiration and biopsy in different bones or two separate skin incisions over the same bone." (Note: You'll need to append a modifier to 38220 to override the edit.) When the physician performs bone marrow aspiration and biopsy at the same site through the same skin incision, you should not report 38220 in addition to 38221. Instead, "G0364 may be reported to describe the bone marrow aspiration performed with bone marrow biopsy." Resource: