Question: Montana Subscriber Answer: Modifier 21 rules: For example, in the "Office or Other Outpatient Services" E/M section of CPT 2008, the only codes that allow for modifier 21 use are 99205 (Office or other outpatient visit for the E/M of a new patient, which requires these three key components: a comprehensive history; a comprehensive examination; medical decision-making of high complexity) and 99215 (Office or other outpatient visit for the E/M of an established patient, which requires at least two of these three key components: a comprehensive history; a comprehensive examination; medical decision-making of high complexity). Be aware: Modifier 21 use is quite uncommon, and Medicare has pretty strict rules governing its use. Before using modifier 21, be sure to check with your payer to see if the modifier fits your coding situation.