Question: Alabama Subscriber Answer: CPT has several strep test codes that you should assign based on the test's methodology. You would instead use 87081 (Culture, presumptive, pathogenic organisms, screening only) if your office does the culture, which is commonly used as a back-up to the rapid strep test. If a patient presents with a sore throat and beefy red pharynx, many physicians will order two swabs, one for a rapid strep test and one for a culture, if necessary. If the physician office lab conducts the rapid strep test and the findings are positive, the second swab often is discarded and the culture is not carried out. You would code this as 87880 and the strep diagnosis. Code 86403 (Particle agglutination; screen, each antibody) is for testing blood and is subject to CLIA edits. That is why you would use 86403 in combination with venipuncture (36415, Collection of venous blood by venipuncture) or a blood draw (36416, Collection of capillary blood specimen [e.g., finger, heel, ear stick]).