Distinguish hormonal or pre-malignant hyperplasia with expanded 621.3. "Although many pathologists have moved to a two-level endometrial classification that distinguishes benign estrogen-induced changes from emergent pre-cancerous lesions, some pathologists persist with the older, four-tier descriptive hyperplasia classification," says Melanie Witt, RN, CPC, COBGC, MA, a coding expert based in Guadalupita, N.M. That's why ICD-9 2010 adds two new codes -- and keeps four old codes -- under 621.3 (Endometrial hyperplasia). Use the following guidelines to help you get your 621.3x coding right -- every time. Assorted Adjectives and 'Atypia' Signal Older Codes Since 2005, coders have had the following four codes to describe endometrial hyperplasia: • 621.30 -- Endometrial hyperplasia, unspecified • 621.31 -- Simple endometrial hyperplasia without atypia • 621.32 -- Complex endometrial hyperplasia without atypia • 621.33 -- Endometrial hyperplasia with atypia. These codes align fairly well with the four-class World Health Organization (WHO) diagnostic system for endometrial hyperplasia that subdivides the findings according to architectural complexity (simple versus complex) and the presence of cytologic atypia. Pathologists might also use related descriptors for the hyperplasia, such as "mild," "severe," and "atypical." Although most pathologists now adhere to a newer, two-tier classification system that prompted the new ICD-9 codes, these older codes remain in place. Do this: Pay special attention to the ICD-9 text notes, which will help you select the proper code. For instance, ICD-9 2010 lists the following descriptors under 621.30: • Hyperplasia (adenomatous) (cystic) (glandular) of endometrium • Hyperplastic endometritis. That means you should use the "unspecified" endometrial hyperplasia code (621.30) if you see any of these terms. Tip: 'EIN' and 'Benign Hyperplasia' Warrant New Codes When you code a pathology report that uses the newer classification for endometrial hyperplasia, get ready to use two new ICD-9 2010 codes as follows: • 621.34 -- Benign endometrial hyperplasia • 621.35 -- Endometrial intraepithelial neoplasia (EIN). "ICD-9 introduced these new codes because pathologists increasingly use a disease classification that distinguishes the benign hormonal effects of unopposed estrogens (benign hyperplasia) from emergent precancerous lesions (endometrial intraepithelial neoplasia [EIN])," Witt explains. Do this: Old way: • For EIN you may have used either 233.2 (Carcinoma in situ of other and unspecified parts of uterus) or 621.33. Remember to change this to 621.35. • For benign hyperplasia you might have used 621.30 or 621.31. Remember to change this to 621.34. Know the Specimen Source When will you use assign a code from the range 621.30 to 621.35? When your pathologist diagnoses an endometrial tissue specimen from a surgical procedure such as colposcopy or hysterectomy. You should be familiar with the following CPT codes, as well as a wide range of specimen terminology that you might see in endometrial pathology reports: • 88305 -- Level IV -- Surgical pathology, gross and microscopic examination, endometrium, curettings/biopsy • 88307 -- Level V -- Surgical pathology, gross and microscopic examination, uterus, with or without tubes and ovaries, other than neoplastic/prolapse. Roadblock: You might see other terms in the pathology report that could describe specimens with endometrial hyperplasia. You'll have to recognize these terms if you want to report the correct procedure and diagnosis codes. Some of the terminology you might see in your pathologist's documentation includes: • EMC -- This is a common abbreviation for endometrial curettings. "When you see the specimen described as EMC, you should report the procedure as 88305," says Tina Burkhalter, billing manager with SouthEastern Pathology in Rome, Ga. • Myometrium -- • Hysterectomy --