Pathology/Lab Coding Alert

Reader Questions:

Find New Epilepsy GSP Code

Question: I’ve heard there is a new “epilepsy panel” that targets gene mutations to help identify genetic predisposition to the condition in patients with a familial connection. What is the code?

Georgia Subscriber

Answer: CPT® 2021 adds code 81419 (Epilepsy genomic sequence analysis panel, must include analyses for ALDH7A1, CACNA1A, CDKL5, CHD2, GABRG2, GRIN2A, KCNQ2, MECP2, PCDH19, POLG, PRRT2, SCN1A, SCN1B, SCN2A, SCN8A, SLC2A1, SLC9A6, STXBP1, SYNGAP1, TCF4, TPP1, TSC1, TSC2, and ZEB2), which may be the test you’re referring to.

This is a genomic sequencing procedure (GSP), which means that the test simultaneously interrogates multiple genes or genetic regions related to a specific condition — epilepsy in this case.

Although many GSP procedures use next generation sequencing (NGS) technology, that’s not a requirement for reporting the code. The key to reporting 81419 is that the test must include analysis of at least the 24 genes listed in the code.

The 81419 test results may help diagnose epilepsy, distinguish forms of the condition, or serve as predictive testing for inherited disease.