Question: Texas Subscriber Answer: Caution: Although elevated total calcium is a common indicator of possible hyperparathyroidism, some studies point to ionized calcium as a more discriminating indicator, especially for borderline hyperparathyroidism. Parathyroid hormone, produced by the parathyroid glands, controls calcium, phosphorus and vitamin D levels in the blood. Primary hyperparathyroidism occurs when an enlarged parathyroid gland leads to too much hormone, which raises the level of calcium in the blood.