Question: Tennessee Subscriber Answer: The column 1/column 2 edit table generally involves procedures in which the code in column 2 is a component of the column 1 code. In contrast, the mutually exclusive table deals with codes that would rarely be performed together because, for instance, they represents two tests for the same analyte using different methodology. Whether the edit pair is on the column 1/column 2 table or the mutually exclusive table, you need to look at the modifier indicator column to learn if you can override the edit pair when clinical circumstances warrant doing so. In your example, because the physician ordered two distinct tests at two separate patient encounters, and the CCI table modifier indicator is "1" (modifier allowed), you should bill the service as 82310, 82331-59 (Distinct procedural service). You can find the CCI edits on the CMS website at http://www.cms.gov/NationalCorrectCodiNitEd/01_overview.asp . Or, you can use a CCI edit look-up tool at https://www.aapc.com/codes/.