Question: Maryland Subscriber Answer: Long-standing AMA instruction allows you to report each cytology preparation as a distinct service. In other words, if the pathologist needs to examine both a direct smear (88104, Cytopathology, fluids, washings or brushings, except cervical or vaginal; smears with interpretation) and a concentrated smear (88108 Cytopathology, concentration technique, smears and interpretation [e.g., Saccomanno technique]) to reach a diagnosis, you can bill separately for each preparation. Beware Medicare: The CCI Policy Manual instructions state that Medicare considers different cytology preparations a "duplicate" service. If the pathologist uses two preparations, you should bill only for the more comprehensive procedure. That means you should bill your example to Medicare as 88108. You should not additionally report 88104. Even though using modifier 59 (Distinct procedural service) would override the edit pair, you should not use 59 when you're billing for one specimen. Reserve modifier 59 for cases when the pathologist examines a direct smear and a concentrated smear from two different specimens on the same day.