Question: Answer: You should report the biopsy with 38221 (Bone marrow; biopsy, needle, or trocar) and choose the appropriate E/M code based on the documentation. Be sure to append modifier 25 (Significant, separately identifiable evaluation and management service by the same physician on the same day of the procedure or other service) to the E/M code to indicate the separate nature of the service. Helpful hint: Experts recommend asking yourself three questions when deciding if your case meets the criteria: 1. Could the complaint or problem stand alone as a billable service? 2. Do you have a different diagnosis for the portion of the visit unrelated to the initial service? (CPT explicitly states separate diagnoses aren't a requirement, but they can be a helpful clue, experts note.) 3. Did your physician perform extra work that went above and beyond the typical pre- or postoperative work associated with the procedure code? If you can answer "yes" to any of those questions, you're one step closer to reporting modifier 25 correctly. Don't miss biopsy exam: