Question: Montana Subscriber Answer: Here's the difference between the two codes: • In 64450, the physician injects a local anesthetic into the branch of the nerve being anesthetized for pain control or blockage. You use 64450 for nerve blocks of nerves that don't have a specific CPT code listed in the section of somatic nerve injections. • With 20526, the physician administers a single therapeutic injection of corticosteroid and/or anesthetic at the wrist crease into the carpal tunnel. The injection treats a neuropathy of the median nerve as it passes through the carpal tunnel and helps provide temporary relief of carpal tunnel syndrome symptoms.