These instruction changes aim to answer common infusion admin questions. At first glance, the CPT® 2012 manual seems to present a completely overhauled set of infusion administration guidelines. But if you're confused about what exactly is new, you aren't alone. Good news: The revisions offer a great incentive to review the guidelines, check them against your own coding, and make any adjustments needed to ensure clean, compliant claims. Several highlights are covered below, but be sure to read all of the guidelines for yourself. You'll find the "Hydration, Therapeutic, Prophylactic, Diagnostic Injections and Infusions, and Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration" guidelines located before 96360 (Intravenous infusion, hydration; initial, 31 minutes to 1 hour) in your manual. Watch for Supported Office/Outpatient E/M Visit The revised guidelines add details on which E/M codes you may report in addition to the infusion administration codes, said Peter A. Hollmann, MD, AMA CPT® Editorial Panel Chair, at the CPT® and RBRVS 2012 Annual Symposium. From the 2011 guidelines, you already know that your physician may report a significant, separately identifiable E/M service in addition to the infusion service code by appending modifier 25 (Significant, separately identifiable evaluation and management service by the same physician on the same day of the procedure or other service) to the E/M code. The 2012 guidelines go a step further by stating if a separately identifiable E/M is performed, you should report a distinct "office or other outpatient" E/M service. To underscore the point further, the guidelines list the possible office/outpatient codes: In a typical case, a physician reporting an E/M and infusion admin for the same patient will be performing both in the office setting. This is because physicians should not submit claims for most infusions performed in a facility. As the guidelines state, infusion admin codes "96360-96379, 96402, 96409-96425, 96521-96523 are not intended to be reported by the physician in the facility setting." Caution: Review When 2 Initial Codes Are OK The 2012 guidelines go into more detail than the 2011 guidelines did on the meanings of initial, sequential, and concurrent when used in the infusion code definitions, Hollmann explained. The guidelines also offer practical information on how to apply the codes. Initial example: The 2012 definition for initial infusion adds that when "protocol or patient condition" requires two IV sites, you may report a second initial infusion with modifier 59 (Distinct procedural service) appended. Encourage your providers to document, in a patient-specific order, the medical need for two IV sites when not based on a clinically accepted, standard, medication-specific protocol, experts advise. Also, when provided in this manner, the second IV site should be clearly represented in the infusion nurse's documentation to support the second initial CPT® code selection. Look: Sequential example: The bottom line is that a "sequential" infusion identifies infusion of a new substance/drug. This is in contrast to a subsequent infusion, which describes the second or subsequent infusion of the same substance/drug (the subsequent code definition typically includes "each additional hour"). Know Which DOS Applies for 2-Day Infusion As a physician coder, you may not encounter too many midnight infusions, but the updated guidelines offer helpful instructions in case you do. The scenario is more common for facilities. Continuous: Not continuous: Report Hydration Ordered to Prevent Toxicity The 2012 guidelines offer important pointers for hydration given before and after chemotherapy or other drugs to prevent certain toxicities. Can you report that hydration? CPT® guidelines say yes. The infusion must meet the minimum time requirement of 31 minutes for you to report a hydration code, the guidelines state. As a coder, you want to be sure the documentation clearly indicates the physician ordered the hydration to prevent a possible toxicity that the administered drug could cause. Caution: