Here’s why you should have modifiers 22, 25 at the ready. If you’re assuming the number of samples your ob-gyn takes equals the number of biopsy coding units you should report, then you could be setting yourself up for a costly denial—not to mention a headache. Check out these three scenarios, and see if your solutions match the expert advice. Background: A biopsy is a tissue sample that the ob-gyn excises from the patient to ascertain the presence of cancer. Ob-gyns will most likely perform biopsies of the vulva, cervix, vagina, endometrium, and ovary(s). Ob-gyns usually order a biopsy as a result of abnormal vaginal bleeding or after the detection of a mass, cyst, lump, tumor, or cells of abnormal appearance. Best bet: You should code all your biopsies with the copy of the pathology report to back up your diagnoses. Make this a rule when you’re coding biopsies, and your claim is sure to sail. Lap-to-Open Biopsy Procedure Requires This Code Scenario: The ob-gyn performs an ovarian biopsy laparoscopically on the left side. The biopsy reveals malignancy, so the ob-gyn converts to an open procedure to remove the ovary(s). What should you report? What you should do: The code for a laparoscopic ovarian biopsy is 49321 (Laparoscopy, surgical; with biopsy [single or multiple]). If the intraoperative biopsy reveals malignancy, the ob-gyn may convert to an open procedure to remove the ovary(s) (for example, 58940, Oophorectomy, partial or total, unilateral or bilateral). Note: You cannot report 58950 (Resection (initial) of ovarian, tubal or primary peritoneal malignancy with bilateral salpingo-oophorectomy and omentectomy) even though the results came back as a malignancy, because the ob-gyn did not perform an omentectomy. At this point, most payers will consider the biopsy part of the more extensive procedure, but some may reimburse 49321 separately, especially if future surgery was contingent on the biopsy result (i.e., the patient was not originally scheduled for a BSO). If the work involved in performing the laparoscopy and obtaining the biopsy was significant and well documented, you may alternatively use modifier 22 (Increased procedural services) appended onto 58940 (Oophorectomy, partial or total, unilateral or bilateral) to obtain higher reimbursement. Your payer will decide if they want it billed separately or if they want the extensive procedure with modifier 22 option. Don’t forget: If the ovarian biopsy revealed malignancy, you’ll likely attach a diagnosis like malignant ovarian neoplasm (C56.2, Malignant neoplasm of left ovary) for 58940. Be careful though. You should never report a code for malignancy because the ob-gyn states it looks malignant without pathology confirming it. Look for These Additional Coding Opportunities Scenario: A patient with irregular intermenstrual bleeding (N92.1, Excessive and frequent menstruation with irregular cycle) undergoes an office procedure in which the ob-gyn extracts samples from the tissue lining the inside of the uterus (endometrium). He inserts a plastic catheter into the uterus and suctions out a small amount of the endometrial lining. What should you report? What you should do: This is an endometrial biopsy, so you should report 58100 (Endometrial sampling [biopsy] with or without endocervical sampling [biopsy], without cervical dilation, any method [separate procedure]). This code represents a fairly straightforward procedure that an ob-gyn does in the office, without general or local anesthesia in most cases. Keep in mind: You can report 58100 with a preventive or problem-oriented E/M visit by attaching modifier 25 (Significant, separately identifiable Evaluation and Management service by the same physician or other qualified health care professional on the same day of the procedure or other service) to the E/M code if the ob-gyn documented a separate significant E/M service. If the patient reports for a biopsy and the ob-gyn planned or conducted no other service, however, you should report the biopsy code on its own. Also, if your ob-gyn performs an endometrial biopsy in addition to a colposcopy, you should use the add-on code +58110 for the biopsy (Endometrial sampling [biopsy] performed in conjunction with colposcopy [List separately in addition to code for primary procedure]) instead of 58100. Count Your Lesions Carefully Scenario: A patient presents with three mole-like lesions on the on the vulva that haven’t responded to topical or other conventional treatments. With topical anesthesia, the ob-gyn takes a sample from each of three identified lesions. What should you report? What you should do: The CPT® codes for vulva biopsy are 56605 (Biopsy of vulva or perineum [separate procedure]; 1 lesion) and +56606 (... each separate additional lesion [List separately in addition to code for primary procedure]). Code +56606 is an add-on code, and its definition indicates that you can report it in multiples— in other words, for every lesion the ob-gyn excises after the first one. If the ob-gyn biopsies three separate lesions, the claim form would read, line by line: You should note that there is no modifier listed with +56606 because this code is an add-on code that does not require one. Heads up: You should not report all biopsies this way. In the case of a colposcopy and biopsy(s) of the cervix (57455, Colposcopy of the cervix including upper/adjacent vagina; with biopsy[s] of the cervix), you should only submit one code— even if the ob-gyn takes three samples in the same area. The lab will bill for the three specimens it received. Also note, that if the physician had taken three samples of a single lesion, you would only report 56605.