Question: A patient presents with a tumor of the cerebrum. The physician biopsies the tumor and sends it to pathology. The patient returns for a follow-up consultation, where the physician explains that the pathology results are inconclusive and she needs to do more testing. What diagnosis code should I apply? Idaho Subscriber Answer: You will not come across this sort of diagnostic coding scenario often in real-time, but it's important to know how to code it if and when the situation arises. What is initially clear is that based on the inconclusive biopsy results, you will not be coding this tumor as malignant or benign. Because of this, your window of possible diagnosis codes becomes extensively smaller. When you look up Tumor in the ICD-10 index, it directs you toward "see also Neoplasm, unspecified behavior, by site." You are then directed to the Table of Neoplasms, where you should first look for a neoplasm of the brain. Under brain NEC, you find cerebrum, which gives you the option of coding as malignant, benign, in situ, uncertain, and of unspecified behavior. Since you can immediately rule out the first three options, your coding choices come down to D43.0 (Neoplasm of uncertain behavior of brain, supratentorial) and D49.6 (Neoplasm of unspecified behavior of brain). Consider these ICD-10 coding guidelines when making a coding determination on this case. Under Section 1.A.9.b, the guidelines state: "Codes titled 'unspecified' are for use when the information in the medical record is insufficient to assign a more specific code." So, unspecified behavior means that the physician is currently unable to determine the behavior of the neoplasm. Uncertain behavior, on the other hand, is actually a definitively inconclusive diagnosis. That is, the provider has concluded that the behavior of the neoplasm cannot be determined at this time. Despite the fact that the provider has recommended follow-up testing to determine the behavior of the neoplasm, you can confidently conclude that the neoplasm falls under the "of uncertain behavior" coding category due to the "conclusively inconclusive" pathology results. As a general rule, if pathology testing has been performed and results are documented in the medical record, you should not consider the use of an "unspecified behavior" code. Whether or not the nature of the neoplasm is known, the results are still definitively conclusive or inconclusive. You will apply code D43.0 either as a definitive, final diagnosis or until further testing can be performed.