Question: What is the correct diagnosis for Alexander disease? Kentucky Subscriber Answer: Several diagnoses could apply to Alexander disease, so get more details from your physician before coding. Options include 728.89 (Other disorders of muscle, ligament, and fascia; other), 288.2 (Genetic anomalies of leukocytes), 288.3 (Eosinophilia), 710.5 (Eosinophilia myalgia syndrome) and 710.8 (Other specified diffuse diseases of connective tissue). What it is: According to Stedman's Medical Dictionary, Alexander disease is a rare, fatal central nervous system degenerative disease of infants. The disease is characterized by psychomotor retardation, seizures and paralysis. Patients might also experience megaloencephaly and widespread leukodystrophic changes.