Question: During a colonoscopy, our surgeon documented removing a large colon polyp using endoscopic submucosal dissection (ESD). Should I report this as 45390? Ohio Subscriber Answer: No, you should not report 45390 (Colonoscopy, flexible; with endoscopic mucosal resection) for endoscopic submucosal dissection (ESD). Although similar, the submucosal dissection is a different procedure. Depending on the payer, you may report the service using HCPCS Level II code C9779 (Endoscopic submucosal dissection (esd), including endoscopy or colonoscopy, mucosal closure, when performed). For other payers you may need to use an unlisted CPT® code, such as 45399 (Unlisted procedure, colon). To use the endoscopic mucosal resection (EMR) code such as 45390, the note should indicate the following steps: Note: CPT provides other codes for EMR: