The outermost skin layer, the epidermis, varies in thickness from 0.05 mm (the eyelids) to 1.5 mm or more (for instance, in the soles of the feet), and is made up of five layers.
The stratum corneum, or surface layer (also called the -horny layer-), is comprised of dead, flat skin cells that shed regularly. Beneath this layer are (in order) the stratum lucidum, stratum granulosum, stratum spinosum and stratum basale.
The stratum basale (or basal layer), the innermost epidermal layer, is where new skin cells develop. The cells flatten and die as they migrate through the three middle epidermal layers (collectively called the squamous layer) to the stratum corneum.
The epidermis contains no blood vessels and is entirely dependent on the underlying dermis for nutrient delivery and waste disposal.
Between the epidermis and dermis lies the dermoepidermal junction, which is composed of two layers: the lamina lucida (closest to the epidermis) and lamina densa (closest to the dermis).
The dermis, which can range in thickness from 0.3 mm to 3.0 mm, likewise has several layers. These are called the papillary layer, which contains thin collagen fibers, and the reticular layer, which contains thicker collagen fibers arranged parallel to the skin's surface.
Both dermal layers contain elastic and reticular fibers, in addition to collagen, throughout. The dermis also contains blood vessels, lymph vessels, hair follicles and sweat glands. The dermis- primary function is to sustain and support the epidermis.
The subcutis, also called the subcutaneous layer, hypodermis or panniculus adiposus, is soft tissue that lies just under the skin. It consists of a network of collagen and fat cells, as well as nerves and blood vessels.
Important: The integumentary system does not extend into the muscle or bone below the subcutis. In most cases, the fascia surrounding the muscle forms the border between the integumentary system and the musculoskeletal system.