Question: Utah Subscriber Answer: In this case, you would choose 45385 (with the higher RVU), and place it in the primary position, while 45384 goes in the secondary position. The lesser value code (45384) will be paid at full price minus the cost of the diagnostic service. Appending modifier 59 would tell the insurance carrier that the lesions were different and were removed from different areas of the colon. Exception: Good idea: For example, you may report 211.3 (Benign neoplasm of colon) for hot forceps removal in ascending colon, and 211.4 (Benign neoplasm of rectum and anal canal) for rectosigmoid. Sometimes it works if a practice would use operative notes and pathology reports to show the location and status of the lesion.