Question: Kentucky Subscriber Answer: No, you should not report both 45378 (Colonoscopy, flexible, proximal to splenic flexure; diagnostic, with or without collection of specimen[s] by brushing or washing, with or without colon decompression [separate procedure]) and G0105 (Colorectal cancer screening; colonoscopy on individual at high risk). Each of these codes describes colonoscopy, and reporting them both during the same session would be double-billing. In this case, the colonoscopy is diagnostic rather than screening, with a primary diagnosis of 578.1 (Blood in stool). Therefore, you should report 45378 only. You may, however, cite V16.0 (Family history of malignant neoplasm; gastrointestinal tract) as a secondary diagnosis.