Question: In this procedure, the doctor performs an endoscopy and takes a biopsy every 20 centimeters or so. How should I code this? California Subscriber Answer: If the procedure is unusually extensive or time consuming, you could append modifier 22 (Increased procedural services). You would have to provide the payer with a well-documented and convincing argument -- comparison of time with a normal biopsy procedure, number of biopsies and sites, substantial complications -- as to why it should give your office additional reimbursement. Even then, you shouldn't hold your breath in anticipation of extra money.