Question: Ohio Subscriber Answer: The code 45381 is more apt in situations wherein your gastroenterologist is injecting a substance like India ink to help mark the polyp or lesion or injecting saline or hyaluronic acid to create a lift or pillow. This will enable easy removal. But, if your gastroenterologist's sole intention of using an injection was control of bleeding in the site, then you could use 45382 (Colonoscopy, flexible, proximal to splenic flexure; with control of bleeding [eg, injection, bipolar cautery, unipolar cautery, laser, heater probe, stapler, plasma coagulator]) and not 45381. This assumes that the bleeding was not caused by the gastroenterologist during the procedure.