Question: Can you explain the anticoagulant management codes to me? Are they billable and how do you bill them along with an E/M code? South Dakota Subscriber Answer: According to CPT®, “Anticoagulant services are intended to describe the outpatient management of warfarin therapy, including ordering, review, and interpretation of International Normalized Ratio (INR) testing, communication with patient, and dosage adjustments as appropriate.” An anticoagulant is a drug that prevents clot formation within the blood vessels and dissolves any previously formed blood clot. Your anticoagulant management code options are as follows: You should only use the CPT® codes 99363 and 99364 for outpatient services. When you report 99363 or 99364, “the work of anticoagulant management may not be used as a basis for reporting an evaluation and management (E/M) service or care plan oversight time during the reporting period,” according to CPT®. However, if the physician performs a separately identifiable E/M service, you may report the appropriate E/M service code and append modifier 25 (Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service). In other words, the documentation for the anticoagulant management should stand on its own, as should the E/M service. When they are separate and significant, both are reportable. You should never report 99363 or 99364 with the following codes when they address anticoagulation with warfarin management: Also, never report 99363 or 99364 with the following or other code(s) for physician review, interpretation, and patient management of home INR testing for a patient with mechanical heart valve(s):