Get a Head Start on These New CPT® Codes
And note these changes to these Category III, PLA codes. The American Medical Association (AMA) recently posted several CPT® code changes on its website. The mid-year changes are due to its early release schedule. You won’t find these changes to Category I, Category III, and proprietary laboratory analyses (PLA) codes in your code books until 2027, but they are effective July 1, 2026. Category I Code Changes The most recent change to the CPT® Category I code set is the addition of two new immunization codes. The codes were accepted at the February 2026 CPT® Editorial Panel meeting for the 2027 CPT® production cycle. The new immunization codes are: These codes are effective on July 1, following a three-month implementation period beginning April 1. The official release document is available on the AMA’s website. Category III Code Changes On March 26, the AMA posted an errata document regarding a change to a CPT® Category III code descriptor to correct an error: This code was part of a group of codes for the early release 2027 production cycle that were posted on the AMA’s website on Dec. 30, 2025. PLA Code Changes The most recent update to CPT® PLA codes, released April 1 and effective July 1, include the revision of two codes (0522U, 0598U), deletion of four codes (0029U, 0031U, 0423U, 0577U), addition of 29 codes (0631U–0659U), and inclusion of an exclusionary parenthetical note following code 0488U. The new note states, “Do not report 0488U in conjunction with 0632U.” The long descriptor for code 0034U is also corrected by replacing the term “hydroxylase” with the term “hydrolase.” The official document announcing these changes to PLA codes is available on the AMA’s website. Renee Dustman, Managing Editor, Content & Editorial, AAPC
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(A version of this article first appeared on the AAPC Knowledge Center blog)
